Sulfuric Acid → 3-Chloro-4-fluoro-N-methylaniline

HRID 127822ノート

反応式

HRID 127822 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:9](C)[CH:10]=O)[CH:5]=[CH:6][C:7]=1[F:8].S(=O)(=O)(O)O>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[F:8])[NH:9][CH3:10]

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 12876631N-(3-chloro-4-fluorophenyl)N-methylformamide

生成物 1

HCID 128766323-Chloro-4-fluoro-N-methylaniline

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
10 °C

実験手順

A mixture of 42.2 g of 5A and 50 g of concentrated sulfuric acid in 600 ml of water was refluxed for 7 hours. The resulting mixture was charcoaled, filtered, cooled to 10° C. and made alkaline with sodium hydroxide. The resulting mixture was extracted with ether. The extract was dried and the ether evaporated to give 3-chloro-4-fluoro-N-methyl-aniline, (5B), as a yellow oil.

後処理

  1. temperaturewas refluxed for 7 hours
  2. filtrationfiltered
  3. extractionThe resulting mixture was extracted with ether
  4. customThe extract was dried
  5. customthe ether evaporated

出典と根拠

ORDレコード
ord-a95517720cb2420d9d6caa979bbb692f
出典データセット
uspto-grants-1981_03
特許番号
US04257805

反応ノート

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