Hydrochloric Acid → HCID 21163085、化合物

HRID 1278220ノート

反応式

HRID 1278220 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH2:16][OH:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.Cl.[CH3:19]O>>[CH3:19][O:17][CH2:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887Methanol2 回HCID 21163070HCID 21163070、化合物

生成物 1

HCID 21163085HCID 21163085、化合物

実験手順

To a mixture of 0.01 mole of 7-(3-pyridyl)pyrazolo-[1,5-a]pyrimidine-3-methanol in 50 ml. of methanol is added anhydrous hydrochloric acid in 10 ml. of methanol. The mixture is heated on a steam bath for 3 hours and the solvent removed. The residue is partitioned between dichloromethane and aqueous sodium bicarbonate. The dichloromethane solution is dried over magnesium sulfate, concentrated and diluted with hexane to give the product of the example.

後処理

  1. temperatureThe mixture is heated on a steam bath for 3 hours
  2. customthe solvent removed
  3. customThe residue is partitioned between dichloromethane and aqueous sodium bicarbonate
  4. dry with materialThe dichloromethane solution is dried over magnesium sulfate
  5. concentrationconcentrated
  6. additiondiluted with hexane
  7. customto give the product of the example

出典と根拠

ORDレコード
ord-f5620bc89ecd4c4ab9827a403433e477
出典データセット
uspto-grants-1981_07
特許番号
US04281000

反応ノート

読み込み中…