1-Chlorobenzotriazole → HCID 11299190、化合物

HRID 1278223ノート

反応式

HRID 1278223 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][CH:15]=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[Cl:16]N1C2C=CC=CC=2N=N1>ClCCl>[Cl:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

参加物

4

反応物 2

HCID 887611-ChlorobenzotriazoleHCID 11206374HCID 11206374、化合物

生成物 1

HCID 11299190HCID 11299190、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3.92 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine and 3.40 g. of N-chlorobenzotriazole in 100 ml. of dichloromethane is heated on a steam bath for 15 minutes. The mixture is poured into 100 ml. of ice cold 2.5 N sodium hydroxide and the dichloromethane layer is separated and dried over anhydrous sodium sulfate. The dichloromethane extract is passed through a column of hydrous magnesium silicate and the eluent is concentrated and diluted with hexane to give 2.75 g. of the product of the example, m.p. 225°-226° C.

後処理

  1. additionA mixture of 3.92 g
  2. additionThe mixture is poured into 100 ml
  3. customof ice cold 2.5 N sodium hydroxide and the dichloromethane layer is separated
  4. dry with materialdried over anhydrous sodium sulfate
  5. extractionThe dichloromethane extract
  6. concentrationthe eluent is concentrated
  7. additiondiluted with hexane
  8. customto give 2.75 g

出典と根拠

ORDレコード
ord-ab6a0ac92f9e4ee9aa8abd728e46c622
出典データセット
uspto-grants-1981_07
特許番号
US04281000

反応ノート

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