Hydrochloric Acid → 5,5-Bis(4-hydroxyphenyl)hydantoin

HRID 1278256ノート

反応式

HRID 1278256 の反応式
[OH:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=O)=[CH:4][CH:3]=1.[C-]#[N:18].[K+].[C:20](=[O:23])([O-])[O-].[NH4+].[NH4+].[CH:26]([NH2:28])=[O:27].Cl>O>[OH:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]2([C:8]3[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=3)[NH:18][C:26](=[O:27])[NH:28][C:20]2=[O:23])=[CH:4][CH:3]=1

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 713FormamideHCID 9032Potassium CyanideHCID 691504,4'-DihydroxybenzophenoneHCID 517111Ammonium Carbonate

生成物 1

HCID 1488755,5-Bis(4-hydroxyphenyl)hydantoin

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

100 Grams of 4,4'-dihydroxybenzophenone, 152.1 g of potassium cyanide and 426.3 g of ammonium carbonate were heated to 120° C. together with 750 ml. of formamide and 150 ml. of water with stirring in an autoclave for 48 hours. The reaction liquid was made acidic with concentrated hydrochloric acid, mixed with water and allowed to stand overnight. The precipitates thus formed were filtered out. The precipitates were decolorized by active carbon and recrystallized from 50% methanol to obtain 111.4 g of 5,5-bis(4-hydroxyphenyl)hydantoin in the form of white crystals.

後処理

  1. customThe reaction liquid
  2. customThe precipitates thus
  3. customformed
  4. filtrationwere filtered out
  5. customrecrystallized from 50% methanol

出典と根拠

ORDレコード
ord-e76319feab26461eaadea0e8e0d9208d
出典データセット
uspto-grants-1981_07
特許番号
US04281009

反応ノート

読み込み中…