Lactic Acid → 1-Carboxyethyl 4-(allylamino)phenylacetate

HRID 1278313ノート

反応式

HRID 1278313 の反応式
[CH2:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1)[CH:2]=[CH2:3].[C:15]([OH:20])(=[O:19])[CH:16]([CH3:18])O.C1(C)C(S(O)(=O)=O)=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14][CH:16]([C:15]([OH:20])=[O:19])[CH3:18])=[O:13])=[CH:7][CH:6]=1)[CH:2]=[CH2:3]

参加物

5

反応物 3

HCID 612Lactic AcidHCID 69252-Methylbenzenesulfonic acidHCID 38316Acetic acid, 2-(p-(allylamino)phenyl)-

生成物 1

HCID 211634791-Carboxyethyl 4-(allylamino)phenylacetate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A flask containing 10.0 g. 4-(allylamino)phenylacetic acid, 3.3 g. lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 24 hours during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon 1-carboxyethyl 4-(allylamino)phenylacetate separates as off-white crystals.

後処理

  1. additionA flask containing 10.0 g
  2. additioncharged
  3. temperatureThe solution is refluxed for 24 hours during which time the Soxhlet extractor
  4. additionis charged twice more with fresh sieves
  5. filtrationThe hot solution is filtered
  6. waitleft
  7. temperatureto cool, whereupon 1-carboxyethyl 4-(allylamino)phenylacetate

出典と根拠

ORDレコード
ord-6622ab184a5541cfa3a43ead1ecfb10d
出典データセット
uspto-grants-1981_07
特許番号
US04281019

反応ノート

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