2,5-Dimethyl-4-benzoquinone → 2,5-Bis((3-(dimethylamino)propyl)thio)-3,6-dimethyl-1,4-benzenediol dihydrochloride

HRID 1278340ノート

反応式

HRID 1278340 の反応式
[CH3:1][C:2]1[C:3](=[O:10])[CH:4]=[C:5]([CH3:9])[C:6](=[O:8])[CH:7]=1.[ClH:11].[CH3:12][N:13]([CH3:18])[CH2:14][CH2:15][CH2:16][SH:17]>C(N(CC)CC)C.CC(C)=O>[ClH:11].[ClH:11].[CH3:12][N:13]([CH3:18])[CH2:14][CH2:15][CH2:16][S:17][C:4]1[C:5]([CH3:9])=[C:6]([OH:8])[C:7]([S:17][CH2:16][CH2:15][CH2:14][N:13]([CH3:18])[CH3:12])=[C:2]([CH3:1])[C:3]=1[OH:10]

参加物

5

反応物 2

HCID 87182,5-Dimethyl-4-benzoquinoneHCID 129471293-(Dimethylamino)propane-1-thiol hydrochloride

生成物 1

HCID 211637562,5-Bis((3-(dimethylamino)propyl)thio)-3,6-dimethyl-1,4-benzenediol dihydrochloride

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 180Acetone溶媒

実験手順

A mixture of 27.2 g (0.200 mole) of 2,5-dimethyl-1,4-benzoquinone, 31.1 g (0.200 mole) of 3-(dimethylamino)propanethiol hydrochloride and six drops of triethylamine in 300 ml of acetone was stirred at ambient temperature for 15 hours. The cream-colored, crude, solid product was collected on a filter and recrystallized from methanol to give the pure product, 2,5-bis((3-(dimethylamino)propyl)thio)-3,6-dimethyl-1,4-benzenediol dihydrochloride, as cream-colored platelets, mp 254.5° C.

後処理

  1. customThe cream-colored, crude, solid product was collected on
  2. filtrationa filter
  3. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-274cec5bb6204b0db2af77c62ea43fcc
出典データセット
uspto-grants-1981_07
特許番号
US04281118

反応ノート

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