Sodium Cyanide → 12-Hydroxydodecanenitrile

HRID 1278385ノート

反応式

HRID 1278385 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[C-:14]#[N:15].[Na+]>CN(C)C=O>[OH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:14]#[N:15]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 7416311-Bromo-1-undecanol

生成物 1

HCID 1033034812-Hydroxydodecanenitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution 4.6 g. of 11-bromoundecanol and 1.6 g. of sodium cyanide in 40 ml. of dimethylformamide is heated at 80° C. for 18 hours, cooled, and poured into ice-water. The mixture is extracted with methylene chloride and the extract is dried over anhydrous magnesium sulfate. Evaporation of the solution affords 12-hydroxydodecanonitrile as a yellow oil.

後処理

  1. temperaturecooled
  2. extractionThe mixture is extracted with methylene chloride
  3. dry with materialthe extract is dried over anhydrous magnesium sulfate
  4. customEvaporation of the solution

出典と根拠

ORDレコード
ord-1d9be8fa42bd4aa28b64c51da6d1f1bc
出典データセット
uspto-grants-1981_07
特許番号
US04281018

反応ノート

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