2-tert-Butyl-1,3-diisopropylisourea → tert-Butyl 3-bromo-2-oxobutanoate

HRID 127889

反応式

HRID 127889 の反応式
[Br:1][CH:2]([CH3:8])[C:3](=[O:7])[C:4]([OH:6])=[O:5].[C:9](OC(=NC(C)C)NC(C)C)([CH3:12])([CH3:11])[CH3:10]>C(Cl)Cl>[Br:1][CH:2]([CH3:8])[C:3](=[O:7])[C:4]([O:6][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:5]

参加物

4

反応物 2

HCID 110417822-tert-Butyl-1,3-diisopropylisoureaHCID 144712563-Bromo-2-oxobutanoic acid

生成物 1

HCID 23470149tert-Butyl 3-bromo-2-oxobutanoate収率 47.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1.6 g (8.85 mmol) of 3-bromo-2-ketobutyric acid and 7 g (4 equivalents) of O-t-butyl-N,N'-diisopropylpseudourea in 14 ml methylene chloride is stirred overnight at room temperature. After filtration, the solution is washed with NaHCO3 and brine, dried and evaporated to an oil which is chromatographed on silica gel with benzene as eluant to give 1 g (45%) of t-butyl 3-bromo-2-ketobutyrate.

後処理

  1. filtrationAfter filtration
  2. washthe solution is washed with NaHCO3 and brine
  3. customdried
  4. customevaporated to an oil which
  5. customis chromatographed on silica gel with benzene as eluant

出典と根拠

ORDレコード
ord-c830d3d5ac4f43b8a99b12c1711f57cb
出典データセット
uspto-grants-1981_03
特許番号
US04257947

関連ノート

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