[l-((4-amino-furo[3,2-c]pyridin-2-yl)methylamino)-2-oxopyrrolidin-3-(S)yl]carbamic acid tert-butyl ester → (7-Methoxynaphthalen-2-yl)sulfonic acid {1-[(4-amino-furo[3,2-c]pyridin-2-yl)methyl]-2-oxopyrrolidin-3-(S)-yl}amide hydrochloride

HRID 1279082

反応式

HRID 1279082 の反応式
[ClH:1].[NH2:2][C:3]1[C:12]2[C:7](=CC=[C:10]([CH2:13][N:14]3[CH2:18][CH2:17][C@H:16]([NH:19][S:20]([C:23]4[CH:32]=[CH:31][C:30]5[C:25](=[CH:26][C:27]([O:33][CH3:34])=[CH:28][CH:29]=5)[CH:24]=4)(=[O:22])=[O:21])[C:15]3=[O:35])[CH:11]=2)[CH:6]=[CH:5][N:4]=1.C([O:40]C(=O)N[C@H]1CCN(NCC2OC3C=CN=C(N)C=3C=2)C1=O)(C)(C)C>>[ClH:1].[NH2:2][C:3]1[C:12]2[CH:11]=[C:10]([CH2:13][N:14]3[CH2:18][CH2:17][C@H:16]([NH:19][S:20]([C:23]4[CH:32]=[CH:31][C:30]5[C:25](=[CH:26][C:27]([O:33][CH3:34])=[CH:28][CH:29]=5)[CH:24]=4)(=[O:22])=[O:21])[C:15]3=[O:35])[O:40][C:7]=2[CH:6]=[CH:5][N:4]=1

参加物

3

反応物 2

HCID 69781651[l-((4-amino-furo[3,2-c]pyridin-2-yl)methylamino)-2-oxopyrrolidin-3-(S)yl]carbamic acid tert-butyl esterHCID 70124326(7-Methoxynaphthalen-2-yl)sulfonic acid {1-[1-amino-7-isoquinolinylmethyl]-2-oxopyrrolidin-3-(S)-yl}amide hydrochloride

生成物 1

HCID 86758425(7-Methoxynaphthalen-2-yl)sulfonic acid {1-[(4-amino-furo[3,2-c]pyridin-2-yl)methyl]-2-oxopyrrolidin-3-(S)-yl}amide hydrochloride

実験手順

Using the procedure described in example 85j 150 mg of [1-((4-amino-furo[3,2-c]pyridin-2-yl)methylamino)-2-oxopyrrolidin-3-(S)yl]carbamic acid tert-butyl ester was transformed into 110 mg of the title compound. MS ESI+: 467 (M+H).

出典と根拠

ORDレコード
ord-76fad386be2b4555883da46c767c9c07
出典データセット
uspto-grants-2002_09
特許番号
US06444672B1

関連ノート

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