化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 16-Mercaptohexadecanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 16-Iodohexadecanoic acid | HCID 41111 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 16-Mercaptohexadecanoic acid | HCID 3522585 | 70% |
反応手順
A mixture of 16-iodohexadecanoic acid (6) (4.0 g, 10.4 mmol) and thiourea (0.88 g, 1.1 equiv.) in ethanol (100 mL) was refluxed overnight under N2 atmosphere. The solution was cooled to room temperature. Sodium hydroxide (1.0 g in 10 mL of water) wad added and the mixture was further heated for 2 hr. After cooling to room temperature 1N HCl was added and the product was extracted using CH2Cl2. The organic extract was dried and evaporated to give a white solid Yield: 2.1 g (69%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06447656B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-48dae631f1574782807114973786c7b2 |
| 出典メモ | uspto-grants-2002_09 |