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Benzyl Bromide → 2-(Hydroxymethyl)-3-(phenylmethoxy)-4H-pyran-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | 3-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one | HCID 9869622 | — |
| 反応物 | 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one | HCID 11139409 | — |
| 生成物 | 2-(Hydroxymethyl)-3-(phenylmethoxy)-4H-pyran-4-one | HCID 21792545 | — |
反応手順
The title compound was prepared by the method outlined for 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one, using 7.1 g (50 mmol, 1 eq.) of 2-hydroxymethyl-3-hydroxy-pyran-4(1H)-one and 9.5 g benzyl bromide (55 mmol 1.1 eq.) to yield the crude product as an organic oil. Further purification by column chromatography on silica gel (eluant: 10% CH3OH/90% CHCl3) furnished the pure product (9.4 g, 81%) as a bright yellow oil. (Looker and Clifton (1986).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06448273B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-c5411fcb1f6449b9840dc8e9cd8ae1f1 |
| 出典メモ | uspto-grants-2002_09 |