Hydrochloric Acid → 1-Ethyl-2-hydroxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride

反応式

[CH2:1]([N:3]1[CH:8]=[CH:7][C:6](=[O:9])[C:5]([O:10]CC2C=CC=CC=2)=[C:4]1[CH2:18][O:19]C)[CH3:2].CO.C(OCC)C.[ClH:28]>>[ClH:28].[CH2:1]([N:3]1[CH:8]=[CH:7][C:6](=[O:9])[C:5]([OH:10])=[C:4]1[CH2:18][OH:19])[CH3:2]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 186788071-Ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one

HCID 21864698Diethyl ether methanol

生成物 1

HCID 699564981-Ethyl-2-hydroxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride収率 73%

実験手順

2.0 g (7.33 mmol) 1-ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one was dissolved in 50 ml of 4N hydrochloric acid and refluxed for 6 hours. Concentration to dryness in vacuo afforded the crude product. Recrystalissaion from methanol/diethyl ether gave the pure title compound (1.1 g, 73%) as a white crystalline solid. m.p. 168-169° C.