Acetic Anhydride → 6-Acetamidopyridine-3-carboxamide

HRID 127943ノート

反応式

HRID 127943 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>CS(C)=O>[C:11]([NH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1)(=[O:13])[CH3:12]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 95006-Aminonicotinamide

生成物 1

HCID 2529266-Acetamidopyridine-3-carboxamide

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

6-Amino nicotinamide 13.7 g (0.1 mole) is dissolved in 100 ml of dimethylsulfoxide and acetic anhydride 14.2 ml (0.15 mole) is added to the above solution. The mixture is stirred at room temperature for 16 hours. White crystals which are formed during the reaction are isolated by filtration and are purified by washing with 0.2 N HCl and ethanol. 6-Acetylamino nicotinamide 9.5 g thus synthesized is practically pure as shown by infrared spectroscopy and thin-layer chromatography.

後処理

  1. customWhite crystals which are formed during the reaction
  2. customare isolated by filtration
  3. customare purified
  4. washby washing with 0.2 N HCl and ethanol
  5. custom6-Acetylamino nicotinamide 9.5 g thus synthesized

出典と根拠

ORDレコード
ord-3882579bd32c45989f054d56f505c570
出典データセット
uspto-grants-1981_03
特許番号
US04258052

反応ノート

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