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Isopropanol → 1-n-Propyl-1-phenyl-2-(3-sulfamoyl-4 chlorobenzoyl) hydrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 3-(Aminosulfonyl)-4-chlorobenzoyl chloride | HCID 3017979 | — |
| 反応物 | 1-Phenyl-1-propylhydrazine | HCID 12327162 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-n-Propyl-1-phenyl-2-(3-sulfamoyl-4 chlorobenzoyl) hydrazine | HCID 15571499 | — |
反応手順
A vigorously stirred mixture of 14.0 g (0.1 mol) 1-phenyl-1-n-propylhydrazine, 8.4 g (0.1 mol) sodium bicarbonate, and 100 ml isopropanol was chilled to 0°-5° C., 23 g (0.09 mol) 3-sulfamoyl-4-chlorobenzoyl chloride was added in one portion, and the reaction mixture was allowed to stir for several hours, gradually warming to room temperature. Dilution with water and refrigeration overnight yielded solid material which was collected and recrystallized from acetone/water, mp. 102° C. (d).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04258059 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-5ad3a84d3190480f938908c1fad147db |
| 出典メモ | uspto-grants-1981_03 |