Ethyl 3-[1-benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-4-nitrobutanoate → 4-[1-Benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-2-pyrrolidone

HRID 1279662ノート

反応式

HRID 1279662 の反応式
[CH2:1]([O:8][CH:9]1[CH2:12][C:11]([CH:21]([CH2:28][N+:29]([O-])=O)[CH2:22][C:23](OCC)=[O:24])([C:13]([O:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[CH2:1]([O:8][CH:9]1[CH2:12][C:11]([CH:21]2[CH2:28][NH:29][C:23](=[O:24])[CH2:22]2)([C:13]([O:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 18427813Ethyl 3-[1-benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-4-nitrobutanoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 184278094-[1-Benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-2-pyrrolidone

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

A 11.45 g (25.26 mmol) portion of crude ethyl 3-[1-benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-4-nitrobutanoate was dissolved in 200 ml of ethanol to which was subsequently added 10 ml of Raney nickel under an atmosphere of nitrogen. After replacing nitrogen with hydrogen, this was stirred at 50° C. for 5 hours under an atmosphere of hydrogen. After cooling in an ice bath, the reaction solution was filtered through celite and then the solvent was evaporated under a reduced pressure to give 6.51 g (19.5 mmol) of the title compound. The thus obtained compound was used in the following reaction without purification.

後処理

  1. temperatureAfter cooling in an ice bath
  2. filtrationthe reaction solution was filtered through celite
  3. customthe solvent was evaporated under a reduced pressure

出典と根拠

ORDレコード
ord-2de2fe1682a446bda0105d8fc41ec897
出典データセット
uspto-grants-2002_09
特許番号
US06448266B1

反応ノート

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