Triethylamine → tert-Butyl (3R)-6-cyclohexyl-3-(3-{[3-(4-morpholinyl)-1-azetidinyl]carbonyl}-1,2,4-oxadiazol-5-yl)hexanoate

A solution of ethyl 5-{(1R)-1 -[2-(tert-butoxy)-2-oxoethyl]-4-cyclohexylbutyl}-1,2,4-oxadiazole-3-carboxylate (Preparation 3) (1.00 g, 2.54 mmol) in ethanol (10 ml) was treated with 4-(3-azetidinyl)morpholine dihydrochloride (2.72 g, 12.6 mmol) and triethylamine (2.56 g, 25 mmol) and the resulting mixture was heated under reflux under a nitrogen atmosphere for 24 hours. The solvent was removed under reduced pressure and the residue was partitioned between ethyl acetate and water. The layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed sequentially with water and brine, dried over anhydrous sodium sulphate, filtered and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel eluting with a gradient system of dichloromethane:methanol (97:3) gradually changing to dichloromethane:methanol (95:5) to afford the title compound as a colourless oil (1.32 g).

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux under a nitrogen atmosphere for 24 hours
3. customThe solvent was removed under reduced pressure
4. customthe residue was partitioned between ethyl acetate and water
5. customThe layers were separated
6. extractionthe aqueous layer was extracted with ethyl acetate
7. washThe combined organic layers were washed sequentially with water and brine
8. dry with materialdried over anhydrous sodium sulphate
9. filtrationfiltered
10. customthe solvent removed under reduced pressure
11. customThe residue was purified by column chromatography on silica gel eluting with a gradient system of dichloromethane:methanol (97:3)

ORDレコード

ord-e6c487d7eb364866a64fb8b9f136a6d2

出典データセット

uspto-grants-2002_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06448278B2