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Trimethyl borate → 2,5-Dimethoxyphenylboronic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethyl borate | HCID 8470 | — |
| 反応物 | Benzene, 2-bromo-1,4-dimethoxy- | HCID 91353 | — |
| 反応物 | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | 2,5-Dimethoxyphenylboronic acid | HCID 2734342 | 99% |
反応手順
This compound was prepared in a manner similar to that of 5-Fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 1-bromo-2,5-dimethoxybenzene (2.00 mL, 13.3 mmol), n-BuLi (2.5 M in hexanes; 5.34 mL, 13.3 mmol), and trimethylborate (4.5 mL, 40 mmol) to afford 2.43 g (99%) of 2,5-dimethoxyphenylboronic acid which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06448405B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-751b4c79d692484790fe287aa70cc713 |
| 出典メモ | uspto-grants-2002_09 |