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Methyl Isocyanate → 6-bromo-3,4-dihydro-4-hydroxy-3-methyl-4-phenyl-2(1H)-quinazolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 反応物 | 2-Amino-5-bromobenzophenone | HCID 99677 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-bromo-3,4-dihydro-4-hydroxy-3-methyl-4-phenyl-2(1H)-quinazolinone | HCID 23471627 | 91.6% |
反応手順
A solution of 14.70 g (0.053 mole) of 2-amino-5-bromobenzophenone and 6.0 g (0.21 mole) of methyl isocyanate in 75 ml of methylene chloride was refluxed for two days and then cooled. The solid portion of the reaction mixture was collected on a filter and washed with methylene chloride to give 16.18 g (90% yield) of 6-bromo-3,4-dihydro-4-hydroxy-3-methyl-4-phenyl-2(1H)-quinazolinone as a white crystalline powder: mp 293°-294° (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04258187 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-ec16b9c2a8b145b5bc7dd1ee90612a19 |
| 出典メモ | uspto-grants-1981_03 |