Hydrochloric Acid → (2R)-2-amino-3-(3-pyridyl)-1-propanol dihydrochloride

HRID 1280596

反応式

HRID 1280596 の反応式
[OH:1][CH2:2][C@H:3]([NH:11]C(=O)C)[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1.[ClH:15]>>[ClH:15].[ClH:15].[NH2:11][C@H:3]([CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)[CH2:2][OH:1]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 23381536N-[(1R)-2-hydroxy-1-(3-pyridylmethyl)ethyl]acetamide

生成物 1

HCID 69885129(2R)-2-amino-3-(3-pyridyl)-1-propanol dihydrochloride

反応条件

温度
100 °C

実験手順

A suspension of 13.55 g of N-[(1R)-2-hydroxy-1-(3-pyridylmethyl)ethyl]acetamide in 110 cm3 of aqueous 6N hydrochloric acid is heated at a temperature in the region of 100° C. for 3 hours. The water is evaporated off under reduced pressure (3 kPa) at a temperature in the region of 50° C. 16.51 g of (2R)-2-amino-3-(3-pyridyl)-1-propanol dihydrochloride are obtained in the form of an off-white solid. [1H NMR spectrum (400 MHz, (CD3)2SO-d6, δ in ppm): 3.13 (d, J=7.5 Hz: 2H); 3.50 (mt: 2H); 3.62 (mt: 1H); 7.94 (dd, J=8 and 5.5 Hz: 1H); 8.27 (unres. mult.: 3H); 8.43 (broad d, J=8 Hz: 1H); 8.79 (broad d, J=5.5 Hz: 1H); 8.86 (broad s: 1H)].

後処理

  1. customThe water is evaporated off under reduced pressure (3 kPa) at a temperature in the region of 50° C

出典と根拠

ORDレコード
ord-554b0e17544d411cbd2b9736c4806e8b
出典データセット
uspto-grants-2002_09
特許番号
US06451821B1

関連ノート

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