1-Iodo-2-(methoxymethoxy)benzene → (RS)-4-{1-[4-(2-Methoxymethoxy-phenyl)-butyl]-pyrrolidine-3-sulfonyl}-phenol
反応式
[CH2:1]([N:5]1[CH2:9][CH2:8][CH:7]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)(=[O:12])=[O:11])[CH2:6]1)[CH2:2][CH:3]=[CH2:4].I[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[O:27][CH2:28][O:29][CH3:30]>>[CH3:30][O:29][CH2:28][O:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[CH2:4][CH2:3][CH2:2][CH2:1][N:5]1[CH2:9][CH2:8][CH:7]([S:10]([C:13]2[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH2:6]1参加物
3
実験手順
The title compound, MS: m/e=420.3 (M+H+) was prepared from (RS)-4-(1-but-3-enyl-pyrrolidine-3-sulfonyl)-phenol and 1-iodo-2-methoxymethoxy-benzene. 1-Iodo-2-methoxymethoxy-benzene is a known compound and has been prepared as described in the following reference: J. R. Labrosse; C. Poncet; P. Lhoste; D. Sinou; Tetrahedron, Asymmetry; 10; 6; 1999; 1069-1078.
出典と根拠
- ORDレコード
- ord-53c8fe976c0b43609f2ec65536de246e
- 出典データセット
- uspto-grants-2002_09