Potassium Hydroxide → HCID 9812939、化合物

HRID 1280756ノート

反応式

HRID 1280756 の反応式
C[O:2][C:3](=[O:14])[CH:4]([F:13])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[OH-].[K+]>CCO>[F:13][CH:4]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:14])=[O:2]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 86584023HCID 86584023、化合物

生成物 1

HCID 9812939HCID 9812939、化合物収率 94.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

(RS)-2-Fluoro-4-phenyl-butyric acid methyl ester (0.39 g, 2 mmol) was added to a solution of KOH (0.56 g, 10 mmol) in EtOH (5 ml). After 1 hour stirring at room temperature. the reaction mixture was concentrated, diluted with H2O (5 ml), acidified to pH 1 with 2N HCl and extracted with CH2Cl2 (3 times). The combined organic phases were dried over Na2SO4, filtered and concentrated to provide (RS)-2-fluoro-4-phenyl-butyric acid (0.343 g, 92%) as a colorless oil MS: m/e=182.1 (M+).

後処理

  1. concentrationthe reaction mixture was concentrated
  2. additiondiluted with H2O (5 ml)
  3. extractionextracted with CH2Cl2 (3 times)
  4. dry with materialThe combined organic phases were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-feddb2f020bd44029ef12e29a1914a5a
出典データセット
uspto-grants-2002_09
特許番号
US06451819B2

反応ノート

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