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N-(2-phenyl-phenylmethyl)-phthalimide → 1-Biphenyl-2-ylmethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-phenyl-phenylmethyl)-phthalimide | HCID 18426122 | — |
| 溶媒 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 生成物 | 1-Biphenyl-2-ylmethanamine | HCID 263366 | 78.9% |
反応手順
N-(2-Phenyl-phenylmethyl)-phthalimide (6.5 g) in 25 cc of hydrazine hydrate were stirred at room temperature overnight. Ice water was added and the solid separated by filtration. The filtrate was salted out with brine and extracted with ethyl acetate. The ethyl acetate extract was washed with water, dried over magnesium sulfate, filtered and concentrated to dryness to afford 3 g of subtitled product as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06451839B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-92513ac2ba0f4915b383c24c79517d71 |
| 出典メモ | uspto-grants-2002_09 |