化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-ethyl-1,5,6,7-tetrahydro-1-(2-phenyl-phenylmethyl)-4H-indol-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 1-Biphenyl-2-ylmethanamine | HCID 263366 | — |
| 反応物 | Ethyl acetate hexane | HCID 21226206 | — |
| 生成物 | 2-ethyl-1,5,6,7-tetrahydro-1-(2-phenyl-phenylmethyl)-4H-indol-4-one | HCID 18426120 | — |
反応手順
2-Phenyl-phenylmethyl amine (3 g, 0.0164 mol) and an equivalent amount of 2-(2-oxobutyl)-1,3-Cyclohexyldione were dissolved in 30 mL of toluene and heated at reflux temperature with a water separator. After several hours, solvent was stripped off and the residue subjected to flash chromatography on silica eluting with 3:1 hexane/ethyl acetate to afford 4.5 g of the subtitled compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06451839B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-7ad3d50b91644ceebdde922da5394e8a |
| 出典メモ | uspto-grants-2002_09 |