HCID 12902850、化合物 → HCID 12902851、化合物

HRID 128085ノート

反応式

HRID 128085 の反応式
[Br:1][C:2]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O>O>[Br:1][C:2]1[C:3]2[O:4][CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:17]=1

参加物

3

反応物 1

HCID 12902850HCID 12902850、化合物

生成物 1

HCID 12902851HCID 12902851、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 156 g. of the product of step A and 1 kg. of polyphosphoric acid is heated at 100° C. for seven days. The reaction mixture is poured into 5 liters of water and stirred, then extracted with 2 liters of chloroform. The dried extracts are treated with decolorizing charcoal, then evaporated. The residue is chromatographed on silica gel, eluting with carbon tetrachloride. The residue is triturated with hexane to provide 7-bromo-3,5-diphenylbenzofuran as a pale yellow solid. The structural assignment is supported by infrared and nuclear magnetic resonance spectral analysis.

後処理

  1. additionA mixture of 156 g
  2. extractionextracted with 2 liters of chloroform
  3. additionThe dried extracts are treated with decolorizing charcoal
  4. customevaporated
  5. customThe residue is chromatographed on silica gel
  6. washeluting with carbon tetrachloride
  7. customThe residue is triturated with hexane

出典と根拠

ORDレコード
ord-04dad6cb6acf471490ce2c2081d16e8a
出典データセット
uspto-grants-1981_03
特許番号
US04258213

反応ノート

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