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Water → 3,5-Diphenyl-4-[(2-methoxyethoxy)methoxy]-benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phenylboronic Acid | HCID 66827 | — |
| 反応物 | 3,5-Diiodo-4-(2-methoxyethoxymethoxy)benzaldehyde | HCID 22237656 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | 3,5-Diphenyl-4-[(2-methoxyethoxy)methoxy]-benzaldehyde | HCID 22237509 | 57% |
反応手順
The title compound was prepared according to the procedure in Example 2, step 3 using 3,5-diiodo-4-(2-methoxyethoxymethoxy)benzaldehyde (4.029 g, 8.721 mmol), phenylboronic acid (2.339 g, 19.19 mmol), palladium(II) acetate (39.16 mg, 0.174 mmol) in DME:H2O. Purification on Biotage KP-Sil eluting with 15% EtOAc/pet. ether gave 1.803 g, (57%) of the title compound. 1H NMR (DMSO-d6) δ 2.78-2.82 (m, 2H), 2.89-2.92 (m, 2H), 3.01 (s, 3H), 4,42 (s, 2H), 7.40-7.54 (m, 6H), 7.62-7.65 (m, 4H), 7.91 (s, 2H), 10.06 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06451845B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-83233f5dca3040a9a3e2cd5714cb1fb2 |
| 出典メモ | uspto-grants-2002_09 |