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HRID 1280974作成日：2026年10月25日
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2-((N-benzoylleucyl)aminomethyl)-1-(4-chlorobenzyl)pyrrolidine
https://huagongshe.com/reaction/1280974
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | Benzoyl-L-leucine | HCID 853887 | — |
| 反応物 | 2-(Aminomethyl)-1-(4-chlorobenzyl)pyrrolidine | HCID 14709036 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 2-((N-benzoylleucyl)aminomethyl)-1-(4-chlorobenzyl)pyrrolidine | HCID 53639429 | — |
反応手順
A solution of 2-(aminomethyl)-1-(4-chlorobenzyl)pyrrolidine (22.5 mg, 0.10 mmol) and dl-benzoylleucine (0.12 mmol) in CHCl3 (1 mL) was treated with EDCI (23 mg), HOBt (16.2 mg) and Et3N (15.2 μL), and stirred at 25° C. for 16 h. The reaction mixture was diluted with CH2Cl2 (0.5 mL), washed with 2 N aqueous NaOH solution (2×0.75 mL), dried by filtration through a PTFE membrane and concentrated to afford 2-{(N-benzoylleucyl)aminomethyl}-1-(4-chlorobenzyl)pyrrolidine (compound No. 344) (74 mg, quant): The purity was determined by RPLC/MS (85%); ESI/MS m/e 442 (M++H, C25H32ClN3O2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06451842B1 |
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| 出典データセット | uspto-grants-2002_09 |
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| ORD ID | ord-8a0de64a23794320bf34e4ed8f6f384a |
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| 出典メモ | uspto-grants-2002_09 |
|---|
