Hydrochloric Acid → 3-(Dimethylamino)-6-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole

HRID 128109

反応式

HRID 128109 の反応式
[CH3:1][N:2]([CH3:10])[CH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.[C:11]([C:14]1[CH:19]=[CH:18][C:17]([NH:20]N)=[CH:16][CH:15]=1)([OH:13])=[O:12].Cl.[CH2:23](O)[CH3:24]>>[CH3:1][N:2]([CH3:10])[CH:3]1[CH2:8][C:7]2[C:18]3[C:17](=[CH:16][CH:15]=[C:14]([C:11]([O:13][CH2:23][CH3:24])=[O:12])[CH:19]=3)[NH:20][C:6]=2[CH2:5][CH2:4]1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 120894-Hydrazinobenzoic acidHCID 103745454-(Dimethylamino)cyclohexan-1-one

生成物 1

HCID 128917863-(Dimethylamino)-6-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole

実験手順

A solution of 15.5 g. of 4-dimethylaminocyclohexanone and 15.2 g. of 4-carboxyphenylhydrazine in 200 ml. of 5-N hydrogen chloride in ethyl alcohol was refluxed for twenty-four hours and the reaction mixture was evaporated to dryness under reduced pressure. The residue was dissolved in water, the aqueous solution was made alkaline with dilute sodium hydroxide and extracted with methylene dichloride and the extract was evaporated to dryness under reduced pressure to give, after recrystallization from isopropyl alcohol, 17.8 g. of 3-(dimethylamino)-6-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole, m.p. 188°-190° C.

後処理

  1. customthe reaction mixture was evaporated to dryness under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with methylene dichloride
  4. customthe extract was evaporated to dryness under reduced pressure
  5. customto give
  6. customafter recrystallization from isopropyl alcohol, 17.8 g

出典と根拠

ORDレコード
ord-5e282fb2fb874c389db8e03174248a7c
出典データセット
uspto-grants-1981_03
特許番号
US04257952

関連ノート

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