反応式
Cl.[CH3:2][N:3]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C:6]1=O)[CH3:4].Cl.[F:13][C:14]1[CH:15]=[C:16]([NH:20]N)[CH:17]=[CH:18][CH:19]=1>C(O)C>[CH3:2][N:3]([CH3:4])[CH:5]1[CH2:10][C:9]2[C:17]3[C:16](=[CH:15][C:14]([F:13])=[CH:19][CH:18]=3)[NH:20][C:8]=2[CH2:7][CH2:6]1参加物
4
実験手順
A solution of 35.5 g. of dimethylaminocyclohexanone hydrochloride and 34.5 g. of 3-fluorophenylhydrazine hydrochloride in 500 ml. of absolute ethyl alcohol was heated at reflux for twenty hours and then cooled in an ice bath. The resulting crystals were collected by filtration, suspended in chloroform, and treated with dilute potassium hydroxide. The chloroform layer was separated and evaporated to dryness under reduced pressure to give, after recrystallization from isopropyl alcohol, 31.5 g. of 3-(dimethylamino)-7-fluoro-1,2,3,4-tetrahydrocarbazole, m.p. 174°-176° C.
後処理
- temperatureat reflux for twenty hours
- temperaturecooled in an ice bath
- filtrationThe resulting crystals were collected by filtration
- additiontreated with dilute potassium hydroxide
- customThe chloroform layer was separated
- customevaporated to dryness under reduced pressure
- customto give
- customafter recrystallization from isopropyl alcohol, 31.5 g
出典と根拠
- ORDレコード
- ord-35d4fee6b18443139088625895e15fa4
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04257952
関連ノート
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