Potassium Carbonate → 3-Cyclopentyloxy-4-methoxybenzaldehyde

HRID 1281179

反応式

HRID 1281179 の反応式
[CH:1]1(Cl)[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:7]=[CH:8][C:9]1[CH:17]=[CH:16][C:13]([O:14][CH3:15])=[C:11]([OH:12])[CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:1]1([O:12][C:11]2[CH:10]=[C:9]([CH:17]=[CH:16][C:13]=2[O:14][CH3:15])[CH:8]=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 12127Isovanillin2 回HCID 70252Chlorocyclopentane

生成物 1

HCID 27358933-Cyclopentyloxy-4-methoxybenzaldehyde

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
122.5 °C

実験手順

A mixture of cyclopentyl chloride (8.48 g, 0.08 moles), isovanillin (6.12 g, 0.04 moles) and potassium carbonate (1.1 g, 0.08 moles) in dimethylformamide (4.04 g) was stirred in the reactor (100 mL) at 120 to 125° C. for 1.5 hours. A sample was taken to verify the batch conversion. Result (GC): 0.5 area % isovanillin (target:≦1.0 area %). The mixture was cooled to 20° C. and filtered to remove the solid (potassium bicarbonate, potassium chloride). The wet cake was washed with methanol.

後処理

  1. customResult (GC)
  2. temperatureThe mixture was cooled to 20° C.
  3. filtrationfiltered
  4. customto remove the solid (potassium bicarbonate, potassium chloride)
  5. washThe wet cake was washed with methanol

出典と根拠

ORDレコード
ord-18e169bec6dc48c3b09d02436c189918
出典データセット
uspto-grants-2002_09
特許番号
US06452022B1

関連ノート

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