4-Aminophenol → Phenol, 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-

HRID 128149

反応式

HRID 128149 の反応式
[CH:1]1[C:6]([NH2:7])=[CH:5][CH:4]=[C:3]([OH:8])[CH:2]=1.Cl[C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=1[N+:20]([O-:22])=[O:21]>C(O)(C)C>[N+:20]([C:11]1[CH:12]=[C:13]([C:16]([F:17])([F:18])[F:19])[CH:14]=[CH:15][C:10]=1[NH:7][C:6]1[CH:5]=[CH:4][C:3]([OH:8])=[CH:2][CH:1]=1)([O-:22])=[O:21]

参加物

4

反応物 2

HCID 4034-AminophenolHCID 84624-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene

生成物 1

HCID 4771887Phenol, 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-収率 94.5%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

6.0 g of p-aminophenol was dissolved in 60 ml of isopropyl alcohol. To the solution was added 6.0 g of 4-chloro-3-nitro-benzotrifluoride and the resulting solution was heated under reflux for 12 hours. After the reaction, the solvent was removed by distillation and the residue was dissolved in benzene. The resulting solution was filtered and the solvent was removed from the filtrate by distillation. Thus, 7.5 g of the desired product was obtained.

後処理

  1. temperaturethe resulting solution was heated
  2. temperatureunder reflux for 12 hours
  3. customAfter the reaction
  4. customthe solvent was removed by distillation
  5. dissolutionthe residue was dissolved in benzene
  6. filtrationThe resulting solution was filtered
  7. customthe solvent was removed from the filtrate by distillation

出典と根拠

ORDレコード
ord-6440437156744dc8be699e3c27fa2396
出典データセット
uspto-grants-1981_03
特許番号
US04259105

関連ノート

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