Acetic Anhydride → (3,4,8-trimethyl-2-oxochromen-7-yl) acetate

HRID 1281641ノート

反応式

HRID 1281641 の反応式
[OH:1][C:2]1[C:11]([CH3:12])=[C:10]2[C:5]([C:6]([CH3:15])=[C:7]([CH3:14])[C:8](=[O:13])[O:9]2)=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([O:1][C:2]1[C:11]([CH3:12])=[C:10]2[C:5]([C:6]([CH3:15])=[C:7]([CH3:14])[C:8](=[O:13])[O:9]2)=[CH:4][CH:3]=1)(=[O:18])[CH3:17]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 53971957-Hydroxy-3,4,8-trimethylcoumarin

生成物 1

HCID 854734(3,4,8-trimethyl-2-oxochromen-7-yl) acetate

実験手順

A solution of 7-hydroxy-3,4,8-trimethylcoumarin (5.19 g, 25.4 mmol) was refluxed in acetic anhydride (10 mL) for 1.5 hours. The solution was slowly poured into ice water (200 mL) and the resulting solid was filtered, then rinsed with water to yield 7-acetoxy-3,4,8-trimethylcoumarin, a beige solid (6.22 g, 99.5%). 1H NMR (CDCl3): δ7.47 (d, J=8.6 Hz, 1H), 7.00 (d, J=8.7 Hz, 1H), 2.40 (s, 3H), 2.37 (s, 3H), 2.29 (s, 3H), 2.22 (s, 3H).

後処理

  1. filtrationthe resulting solid was filtered
  2. washrinsed with water

出典と根拠

ORDレコード
ord-7161f90df0a74543adb054722fe95f24
出典データセット
uspto-grants-2002_09
特許番号
US06455286B1

反応ノート

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