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Ethylamine → HCID 178418290、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylamine | HCID 6341 | — |
| 反応物 | Ethyl 2-(2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate | HCID 54242925 | — |
| 生成物 | HCID 178418290 | HCID 178418290 | — |
反応手順
Employing ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (1.0 g) and 70% aqueous ethylamine solution (0.24 ml), the procedure of Reference Example 8 is repeated to give ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethylaminoacrylate, which is then treated with 60 % sodium hydride (0.15 g) as in Reference Example 9 to give ethyl 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.6 g), as white crystals, m.p. 157°-159° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723648 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-3ed5758e449440ffbc8cbb4a1a1e12a0 |
| 出典メモ | uspto-grants-1998_03 |