Potassium Carbonate → 2-[4-(2-oxo-1,3-Oxazolidin-3-yl)phenyl]propanoic Acid

HRID 1282020

反応式

HRID 1282020 の反応式
Cl[CH2:2][CH2:3][O:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1)=[O:6].C(=O)([O-])[O-].[K+].[K+].C(OC(=O)C)C.C(OC(C)C)(C)C>CN(C)C=O>[O:6]=[C:5]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)[CH2:2][CH2:3][O:4]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 184235752-(4-{[(2-Chloroethoxy)carbonyl]amino}phenyl)propanoic AcidHCID 22281796Diisopropylether ethyl acetate

生成物 1

HCID 120432422-[4-(2-oxo-1,3-Oxazolidin-3-yl)phenyl]propanoic Acid収率 80.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

0.5 g (1.85 mmol) of 2-(4-{[(2-chloroethoxy)carbonyl]amino}phenyl)propanoic acid were dissolved in 10 ml of N,N-dimethylformamide and 0.45 g (3.7 mmol) of potassium carbonate were added. After 48 hours the solvent was evaporated under vacuum, the residue redissolved with dichloromethane and washed with hydrochloric acid 0.5 N. The organic layer was dried over sodium sulphate and evaporated. 0.35 g (80% yield) of the title compound crystallized from a mixture ethylacetate-diisopropylether.

後処理

  1. customAfter 48 hours the solvent was evaporated under vacuum
  2. dissolutionthe residue redissolved with dichloromethane
  3. washwashed with hydrochloric acid 0.5 N
  4. dry with materialThe organic layer was dried over sodium sulphate
  5. customevaporated

出典と根拠

ORDレコード
ord-4e45ff92dcff41428fe741d375b28032
出典データセット
uspto-grants-2002_09
特許番号
US06455559B1

関連ノート

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