Piperazine → 1-(2-Phenylpropyl)piperazine
反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:7][CH:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:9]Br>O.C(O)C>[C:11]1([CH:8]([CH3:9])[CH2:7][N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
5
実験手順
A solution of piperazine (344 g), β-bromoisopropylbenzene (199 g) in water (1 liter) and ethanol (0.35 liter) is refluxed for 24 hours. After cooling, the resulting amine is extracted with 3×0.5 liter methylene chloride. After washing with water and evaporation of the solvent in vacuo, the resulting 2-phenylpropyl piperazine is distilled; b.p.=163°-165° C./15 mm Hg.
後処理
- temperatureAfter cooling
- extractionthe resulting amine is extracted with 3×0.5 liter methylene chloride
- washAfter washing with water and evaporation of the solvent in vacuo
- distillationthe resulting 2-phenylpropyl piperazine is distilled
出典と根拠
- ORDレコード
- ord-410e50dca39446c98a64a81e9efa670f
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04259334
反応ノート
読み込み中…