p-Toluenesulfonic acid monohydrate → 7-Methoxy-2-(tetrahydrofuran-2-yl)-benzofuran
反応式
[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([CH:12]([OH:17])[CH2:13][CH2:14][CH2:15]O)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>ClCCl>[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([CH:12]3[CH2:13][CH2:14][CH2:15][O:17]3)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1参加物
4
実験手順
A solution of 1-(7-methoxybenzofuran-2-yl)-butane-1,4-diol (0.88 g) was treated with p-toluenesulfonic acid monohydrate (10 mg) and 3 Å molecular sieves in dichloromethane (10 ml) at ambient temperature. After stirring for 1 hour the solvent was removed in vacuo. The residue was purified by column chromatography on silica eluting with 20% ethyl acetate in hexane to give the title compound as a yellow oil (0.58 g).
後処理
- customwas removed in vacuo
- customThe residue was purified by column chromatography on silica eluting with 20% ethyl acetate in hexane
出典と根拠
- ORDレコード
- ord-eb973e94b9224c61b7066eccc23f5b70
- 出典データセット
- uspto-grants-2002_09
- 特許番号
- US06455561B1
反応ノート
読み込み中…