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Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-(2-Bromoethoxy)-1,3-dimethylbenzene | HCID 2452208 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine | HCID 23468652 | — |
反応手順
To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259334 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-81ef5e212bdb488faab82b396a9fc6ad |
| 出典メモ | uspto-grants-1981_03 |