1-(2,4-Difluorophenyl)piperazine dihydrochloride → N-(1-(4-(1-(4-(2,4-difluorophenyl)-piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide
反応式
Cl.Cl.[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.Cl[CH:18]([C:20]1[CH:25]=[CH:24][C:23]([C:26]([NH:29][C:30](=[O:32])[CH3:31])([CH3:28])[CH3:27])=[CH:22][CH:21]=1)[CH3:19]>>[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N:11]1[CH2:12][CH2:13][N:14]([CH:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([NH:29][C:30](=[O:32])[CH3:31])([CH3:28])[CH3:27])=[CH:22][CH:21]=2)[CH3:19])[CH2:15][CH2:16]1参加物
3
実験手順
By similar reaction and treatment to that in Example 1(5) using 1-(2,4-difluorophenyl)piperazine dihydrochloride instead of phenylpiperazine and N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide obtained in Example 60(2) instead of N-(4-chloromethylphenylmethyl) acetamide, the title compound was obtained as a white amorphous solid.
後処理
- customBy similar reaction and treatment to that in Example