4-Methoxy-2-(piperazin-1-yl)pyrimidine → HCID 18423183、化合物

HRID 1282176ノート

反応式

HRID 1282176 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][N:20]=[C:19]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[N:18]=1>>[CH3:15][O:16][C:17]1[CH:22]=[CH:21][N:20]=[C:19]([N:23]2[CH2:24][CH2:25][N:26]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=3)[CH2:27][CH2:28]2)[N:18]=1

参加物

3

反応物 2

HCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidineHCID 18423033N-(1-(4-chloromethylphenyl)ethyl)acetamide

生成物 1

HCID 18423183HCID 18423183、化合物

実験手順

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)ethyl)acetamide obtained in Example 48(3) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4-methoxypyrimidin-2-yl)piperazine obtained in Example 98(2) instead of phenylpiperazine, the title compound was obtained as pale-yellow crystals, m.p.=113-115° C.

後処理

  1. customBy similar reaction and treatment to that in Example

出典と根拠

ORDレコード
ord-3e35d75395624521a7cf5c2a26360229
出典データセット
uspto-grants-2002_09
特許番号
US06455528B1

反応ノート

読み込み中…