Ethanol → 1-Acetyl-4-(4,6-diethoxypyrimidin-2-yl)piperazine
反応式
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14](F)[CH:13]=[C:12](F)[N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[O-:18][CH2:19][CH3:20].[Na+].[CH2:22]([OH:24])[CH3:23]>>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14]([O:18][CH2:19][CH3:20])[CH:13]=[C:12]([O:24][CH2:22][CH3:23])[N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]参加物
4
実験手順
A solution of 1-acetyl-4-(4,6-difluoropyrimidin-2-yl)piperazine (1.5 g) and sodium ethoxide (1.3 g) in ethanol (15 ml) was refluxed under heating for 1 hr. The reaction mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (1.8 g) as a pale-brown solid.
後処理
- temperatureunder heating for 1 hr