Water → HCID 18423027、化合物

HRID 1282188ノート

反応式

HRID 1282188 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1.[Br:14][C:15]1[S:19][C:18]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Br:14][C:15]1[S:19][C:18]([N:20]2[CH2:21][CH2:22][N:23]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=3)[CH2:24][CH2:25]2)=[N:17][CH:16]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 15550682N-((4-(chloromethyl)phenyl)methyl)acetamideHCID 184230061-(5-Bromo-1,3-thiazol-2-yl)piperazine

生成物 1

HCID 18423027HCID 18423027、化合物収率 82.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of N-(4-chloromethylphenylmethyl)acetamide (0.9 g), 1-(5-bromothiazol-2-yl)piperazine (1.1 g) and potassium carbonate (0.9 g) in dimethylformamide (10 ml) was stirred at 70° C. for 9 hr. Water (100 ml) was poured into the reaction mixture to allow precipitation of crystals. The crystals were collected by filtration and washed with water to give the title compound (1.5 g) as yellow crystals, m.p.=160-163° C.

後処理

  1. customprecipitation of crystals
  2. filtrationThe crystals were collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-cfee12241c164bfab5c85e3ab6c8f4c2
出典データセット
uspto-grants-2002_09
特許番号
US06455528B1

反応ノート

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