Potassium Hydroxide → Oleoside

HRID 1282252

反応式

HRID 1282252 の反応式
[CH3:1]/[CH:2]=[C:3]1\[C@H:4]([CH2:25][C:26]([O:28]CCC2C=CC(O)=C(O)C=2)=[O:27])[C:5]([C:21]([O:23]C)=[O:22])=[CH:6][O:7][C@H:8]\1[O:9][C@@H:10]1[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]([OH:19])[C@H:11]1[OH:20].[OH-].[K+]>CO.Cl>[CH3:1]/[CH:2]=[C:3]1\[C@H:4]([CH2:25][C:26]([OH:28])=[O:27])[C:5]([C:21]([OH:23])=[O:22])=[CH:6][O:7][C@H:8]\1[O:9][C@@H:10]1[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]([OH:19])[C@H:11]1[OH:20]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 5281544Oleuropein

生成物 1

HCID 101042548Oleoside

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

反応条件

温度
10 °C

実験手順

Oleuropein (1 g) is dispersed in 50 ml of methanol. The solution is cooled to about 10° C. and treated with stirring with about 2 g of potassium hydroxide pellets. The mixture is allowed to warm to room temperature and after about 6 hours, the reaction mixture is diluted with about 60 ml of 6 N HCl (pH about 7.5) and evaporated to dryness. The chromatographic purification of the product mixture provides oleoside [Formula I; R=glycosyl, R1=methyl]. The purified oleoside is formulated into a solid oral dosage form containing about 250 mg of oleoside. Alternatively, oleoside is dissolved in sterile isotonic saline at a concentration of about 5 mg per ml to provide a parenteral dosage form for use in accordance with the method of this invention.

後処理

  1. additiontreated
  2. temperatureto warm to room temperature and after about 6 hours
  3. customevaporated to dryness
  4. customThe chromatographic purification of the product mixture

出典と根拠

ORDレコード
ord-954e2949d6244934bf28f836ffff7c72
出典データセット
uspto-grants-2002_09
特許番号
US06455580B1

関連ノート

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