Imidazole → 1-[2-Cyano-2-(4-phenylthiophenyl)hexyl]imidazole

HRID 128226ノート

反応式

HRID 128226 の反応式
[C:1]([C:3]([C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:4]Br)#[N:2].[NH:23]1[CH:27]=[CH:26][N:25]=[CH:24]1>O>[C:1]([C:3]([C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:4][N:23]1[CH:27]=[CH:26][N:25]=[CH:24]1)#[N:2]

参加物

4

反応物 2

HCID 795ImidazoleHCID 542149592-Cyano-2-(4-phenylthiophenyl)hexyl bromide

生成物 1

HCID 540197231-[2-Cyano-2-(4-phenylthiophenyl)hexyl]imidazole収率 82%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 10 g (0.027 mole) of 2-cyano-2-(4-phenylthiophenyl)hexyl bromide and 8 g (0.13 mole) of imidazole is heated with stirring at 160° for four hours. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are washed with water and dried over Na2SO4. The drying agent is filtered and to the filtrate is bubbled dry hydrogen chloride gas until solution is strongly acidic. The hydrochloride salt is washed with ether and back neutralized with dilute ammonium hydroxide solution to give 8 g of pure product.

後処理

  1. temperatureis heated
  2. extractionextracted with ether
  3. washThe combined ether extracts are washed with water
  4. dry with materialdried over Na2SO4
  5. filtrationThe drying agent is filtered and to the filtrate
  6. customis bubbled dry hydrogen chloride gas until solution
  7. washThe hydrochloride salt is washed with ether

出典と根拠

ORDレコード
ord-b1883a291f8f49158cdfcc690bf2f2d1
出典データセット
uspto-grants-1981_03
特許番号
US04259339

反応ノート

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