Bromine → HCID 23314490、化合物
反応式
[C:1]([C:4]1[C:5]([O:15][CH3:16])=[CH:6][C:7]([O:13][CH3:14])=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10])(=[O:3])[CH3:2].[Br:17]Br>O1CCOCC1>[Br:17][CH2:2][C:1]([C:4]1[C:5]([O:15][CH3:16])=[CH:6][C:7]([O:13][CH3:14])=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10])=[O:3]参加物
4
実験手順
5-Acetyl-2,4-dimethoxybenzoic acid (Ber. 41, 1607, 1908) (21.1 g, 0.094 mole) was stirred in dioxane (200 ml.) at room temperature and bromine (5 ml., ca 0.1 mole) was added dropwise. The bromine colour gradually disappeared over 30 minutes and the mixture was then gently warmed in a steambath for 30 minutes, cooled and the dioxane removed in vacuo. The solid product was treated with boiling ethyl acetate, filtered hot and the filtrate evaporated to give 5-bromoacetyl-2,4-dimethoxybenzoic acid, m.p. 236° C.
後処理
- temperaturethe mixture was then gently warmed in a steambath for 30 minutes
- temperaturecooled
- customthe dioxane removed in vacuo
- additionThe solid product was treated with boiling ethyl acetate
- filtrationfiltered hot
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-a6ccdeb94d7a4daeb6be397e1dc8583d
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04259340
反応ノート
読み込み中…