2-Amino-4-(4-chlorophenyl)thiazole → N-[4-(4-Chlorophenyl)-2-thiazolyl]-4-hydroxy-2-methyl-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

HRID 128271

反応式

HRID 128271 の反応式
[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18](OCC)=[O:19].[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[N:31]=[C:32]([NH2:35])[S:33][CH:34]=2)=[CH:26][CH:25]=1>>[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([C:30]2[N:31]=[C:32]([NH:35][C:18]([C:3]3[N:4]([CH3:17])[S:5](=[O:16])(=[O:15])[C:6]4[C:10]5[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=5[S:8][C:7]=4[C:2]=3[OH:1])=[O:19])[S:33][CH:34]=2)=[CH:28][CH:29]=1

参加物

3

反応物 2

HCID 732412-Amino-4-(4-chlorophenyl)thiazoleHCID 70577588ethyl 4-hydroxy-2-methyl-2H-[1]-benzothieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide

生成物 1

HCID 131712141N-[4-(4-Chlorophenyl)-2-thiazolyl]-4-hydroxy-2-methyl-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide収率 40%

実験手順

Prepared analogous to Example 1 from ethyl 4-hydroxy-2-methyl-2H-[1]-benzothieno [2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and 4-(4-chlorphenyl)-2-thiazolamine with a yield of 40% of theory.

出典と根拠

ORDレコード
ord-57d07d4d877841d0adac4fbd76514492
出典データセット
uspto-grants-1981_03
特許番号
US04259336

関連ノート

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