Phosphorus pentachloride → 2-Chlorocarbonyl-6-methyl-benzo[b] thiophene-3-sulfonic acid chloride

HRID 128281ノート

反応式

HRID 128281 の反応式
[C:1]([C:4]1[S:8][C:7]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:6]=2[C:5]=1[S:14]([O-:17])(=O)=[O:15])(O)=[O:2].[Na+].P(Cl)(Cl)(Cl)(Cl)Cl.[Cl-:25].[Cl-:26].[Cl-].[P+3]=O>>[Cl:25][C:1]([C:4]1[S:8][C:7]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:6]=2[C:5]=1[S:14]([Cl:26])(=[O:17])=[O:15])=[O:2]

参加物

4

反応物 3

HCID 24819Phosphorus pentachlorideHCID 86737645Monosodium 2-carboxy-6-methyl-benzo[b] thiophene-3-sulfonateHCID 178527001HCID 178527001、化合物

生成物 1

HCID 538745162-Chlorocarbonyl-6-methyl-benzo[b] thiophene-3-sulfonic acid chloride収率 82%

実験手順

Prepared analogous to Example 1(b) from monosodium 2-carboxy-6-methyl-benzo[b] thiophene-3-sulfonate and phosphorus-(V)-chloride in the presence of phosphorus oxide trichloride with a yield of 82% of theory. The product, which crystallized upon cooling, was used in the next step without further purification.

後処理

  1. customThe product, which crystallized
  2. temperatureupon cooling
  3. customwas used in the next step without further purification

出典と根拠

ORDレコード
ord-9f28a53b1eba47459e14931769153081
出典データセット
uspto-grants-1981_03
特許番号
US04259336

反応ノート

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