Ammonia → HCID 21520439、化合物
反応式
Br[CH:2]([CH:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9]([F:17])([F:16])[C:8]([F:19])([F:18])[C:7]2[CH:20]=[CH:21][CH:22]=[CH:23][C:6]1=2)[CH2:3][CH3:4].[NH3:24]>>[F:19][C:8]1([F:18])[C:7]2[CH:20]=[CH:21][CH:22]=[CH:23][C:6]=2[CH:5]([CH2:2][CH2:3][CH2:4][NH2:24])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9]1([F:17])[F:16]参加物
3
実験手順
A mixture of 1 gram of 5-(1-bromopropyl)-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene and 20 ml. of liquid ammonia is heated in a sealed tube at 100°C. for 8 hours. After cooling, the ammonia is allowed to evaporate at room temperature and the residual product diluted with ether and the ethereal solution of the product washed with water, dried, and concentrated to leave as a residue 10,11-dihydro-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-propylamine.
後処理
- temperatureAfter cooling
- customto evaporate at room temperature
- additionthe residual product diluted with ether
- washthe ethereal solution of the product washed with water
- customdried
- concentrationconcentrated