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5-Nitro-2-furanmethanediol diacetate → 2-[2-(5-nitro-2-furyl)vinyl]-4-(3H)quinazolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Nitro-2-furanmethanediol diacetate | HCID 7097 | — |
| 反応物 | 5-Nitrofurfural | HCID 12774 | — |
| 反応物 | Anthranilamide hydrochloride | HCID 23509772 | — |
| 反応物 | 4-({2-[2-(5-Nitrofuran-2-yl)ethenyl]quinazolin-4-yl}amino)phenol | HCID 54073999 | — |
| 反応物 | 2-Methyl-4(3H)-quinazolinone | HCID 135400457 | — |
| 生成物 | 2-[2-(5-nitro-2-furyl)vinyl]-4-(3H)quinazolinone | HCID 136114329 | — |
反応手順
This example shows preparation of 2-[2-(5-nitro-2-furyl)vinyl]-4-(p-hydroxyanilino)quinazoline, (V). In this preparation, anthranilamide hydrochloride was converted to 2-methyl-4-(3H)quinazolinone (I) and 5-nitrofurfurylidene diacetate to 5-nitro-2-furancarboxaldehyde (II); (I) and (II) were then reacted to obtain 2-[2-(5-nitro-2-furyl)vinyl]-4-(3H) quinazolinone (III); (III) was then chlorinated to obtain 2-[2-(5-nitro-2-furyl)vinyl]-4-chloroquinazoline (IV) which was reacted with p-aminophenol to obtain the desired product, 2-[2-(5-nitro-2-furyl)vinyl]-4-(p-hydroxyanilino)quinazoline (V) and referred to in subsequent examples as the product of Example I. The procedure in this preparation is as follows:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03973021 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-7949f31e1b6b4dab8fe54c539cf82dd9 |
| 出典メモ | uspto-grants-1976_08 |