Acetic Acid → HCID 178455938、化合物
反応式
[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:21]([N:23]1[CH2:79][CH2:78][CH2:77][C@H:24]1[C:25]([NH:27][C@H:28]([C:36]([N:38]1[CH2:76][CH2:75][CH2:74][C@H:39]1[C:40]([NH:42][C@H:43]([C:49]([NH:51][C@H:52]([C:57]([N:59]1[CH2:73][CH2:72][CH2:71][C@H:60]1[C:61]([N:63]1[CH2:70][CH2:69][CH2:68][C@H:64]1[C:65]([OH:67])=[O:66])=[O:62])=[O:58])[C@H:53]([CH2:55][CH3:56])[CH3:54])=[O:50])[CH2:44][CH2:45][C:46](=[O:48])[NH2:47])=[O:41])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:35])[NH2:34])=[O:26])=[O:22])[CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][CH:13]=1)=[O:8].[N+](=[CH2:82])=[N-].C(O)(=O)C>CO>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:21]([N:23]1[CH2:79][CH2:78][CH2:77][C@H:24]1[C:25]([NH:27][C@H:28]([C:36]([N:38]1[CH2:76][CH2:75][CH2:74][C@H:39]1[C:40]([NH:42][C@H:43]([C:49]([NH:51][C@H:52]([C:57]([N:59]1[CH2:73][CH2:72][CH2:71][C@H:60]1[C:61]([N:63]1[CH2:70][CH2:69][CH2:68][C@H:64]1[C:65]([O:67][CH3:82])=[O:66])=[O:62])=[O:58])[C@H:53]([CH2:55][CH3:56])[CH3:54])=[O:50])[CH2:44][CH2:45][C:46](=[O:48])[NH2:47])=[O:41])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:34])[NH2:35])=[O:26])=[O:22])[CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][CH:13]=1)=[O:8]参加物
5
実験手順
Pyroglutamyl-tryptophyl-prolyl-arginyl-prolyl-glutaminyl-isoleucyl-prolyl-proline (1.6 g) is dissolved in 80 ml of methanol. To this, excess ethereal diazomethane is added and the solution is kept for 7 hours at room temperature. Acetic acid is added to destroy the excess diazomethane and the resulting mixture is concentrated to dryness in vacuo.