o-Phenetidine → 2-(2-Ethoxyanilino)methyl-4-propylmorpholine toluene-p-sulphonate
反応式
[CH2:1]([O:3][C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])[CH3:2].[CH2:11]([N:14]1[CH2:19][CH2:18][O:17][CH:16]([CH2:20][O:21][S:22]([C:25]2[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=2)(=[O:24])=[O:23])[CH2:15]1)[CH2:12][CH3:13]>C1(C)C(C)=CC=CC=1>[C:28]1([CH3:31])[CH:27]=[CH:26][C:25]([S:22]([OH:24])(=[O:21])=[O:23])=[CH:30][CH:29]=1.[CH2:1]([O:3][C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH:6][CH2:20][CH:16]1[O:17][CH2:18][CH2:19][N:14]([CH2:11][CH2:12][CH3:13])[CH2:15]1)[CH3:2]参加物
4
実験手順
A solution of 2-ethoxyaniline (4.8 g.) and 4-n-propyl-2-toluene-p-sulphonyloxymethylmorpholine (10 g.) in xylene (50 ml.) is heated under reflux in an atmosphere of nitrogen for 60 hours. A resinous solid separates from the solvent which is distilled under reduced pressure. The residual sticky solid is washed with ether to give a yellow solid which is crystallised from methanol/ether to give 2-(2-ethoxyanilino)methyl-4-propylmorpholine toluene-p-sulphonate, m.p. 169°-172°C.