Ethyl 2-aminoquinoline-3-carboxylate → Ethyl 3,4-dihydro-4-oxopyrimido(4,5-b)quinoline-2-carboxylate

HRID 1283152

反応式

HRID 1283152 の反応式
[C:1]([C:6](=[NH:8])[O-])([O:3][CH2:4][CH3:5])=[O:2].[NH2:9][C:10]1[C:19]([C:20](OCC)=[O:21])=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1>C(O)C>[N:9]1[C:10]2=[N:11][C:12]3[C:17]([CH:18]=[C:19]2[C:20](=[O:21])[NH:8][C:6]=1[C:1]([O:3][CH2:4][CH3:5])=[O:2])=[CH:16][CH:15]=[CH:14][CH:13]=3

参加物

4

反応物 2

HCID 283477Ethyl 2-aminoquinoline-3-carboxylateHCID 227528221-Carbethoxyformimidate

生成物 1

HCID 135765023Ethyl 3,4-dihydro-4-oxopyrimido(4,5-b)quinoline-2-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The same compound is obtained by: (a) refluxing equimolar amounts of 1-carbethoxyformimidate and ethyl 2-aminoquinoline-3-carboxylate in ethanol for three hours. The reaction mixture is concentrated, the product collected by filtration and recrystallized from hot chloroform; or (b) refluxing equimolar amounts of 1-carbethoxyformamidine and 2-aminoquinoline-3-carboxamide in ethanol for 3-4 hours in the presence of an equimolar amount of sodium ethoxide. The reaction mixture is worked up as described in (a) above.

後処理

  1. concentrationThe reaction mixture is concentrated
  2. filtrationthe product collected by filtration
  3. customrecrystallized from hot chloroform
  4. temperatureor (b) refluxing equimolar amounts of 1-carbethoxyformamidine and 2-aminoquinoline-3-carboxamide in ethanol for 3-4 hours in the presence of an equimolar amount of sodium ethoxide

出典と根拠

ORDレコード
ord-f606fbcb748f4804817a9a76bb3fe748
出典データセット
uspto-grants-1976_08
特許番号
US03974161

関連ノート

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